American Airlines flight AA 5221: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 07:29 Ronald Reagan Washington (DCA) 2 09:07 Detroit (DTW) E AA 5221 Non-stop Canadair CRJ 700 (CR7) 1:38 Effective 2026-04-07 through 2026-05-20
Daily 09:25 Detroit (DTW) E 11:00 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 700 (CR7) 1:35 Effective 2026-04-07 through 2026-05-20
Daily 11:30 Ronald Reagan Washington (DCA) 2 12:41 Madison (MSN) AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:11 Effective 2026-08-05 through 2026-09-08
Daily 12:59 Ronald Reagan Washington (DCA) 2 14:13 Madison (MSN) AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:14 Effective 2026-09-09 through 2026-10-04
Daily 13:12 Madison (MSN) 16:25 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:13 Effective 2026-08-05 through 2026-09-08
Daily 13:44 Ronald Reagan Washington (DCA) 2 14:58 Madison (MSN) AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:14 Effective from 2026-10-05
Sat 13:54 Ronald Reagan Washington (DCA) 2 15:23 Madison (MSN) AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:29 Effective 2026-01-10 through 2026-02-07
Mon-Fri,Sun 13:58 Ronald Reagan Washington (DCA) 2 15:27 Madison (MSN) AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:29 Effective 2026-01-06 through 2026-02-11
Daily 13:59 Ronald Reagan Washington (DCA) 2 15:21 Madison (MSN) AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:22 Valid until 2026-01-05
Mon-Fri,Sun 13:59 Ronald Reagan Washington (DCA) 2 15:30 Madison (MSN) AA 5221 Non-stop Canadair CRJ 900 (CR9) 2:31 Effective 2026-02-12 through 2026-03-06
Sat 14:01 Ronald Reagan Washington (DCA) 2 15:34 Madison (MSN) AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:33 Effective 2026-02-14 through 2026-03-07
Sat 14:01 Ronald Reagan Washington (DCA) 2 15:29 Madison (MSN) AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:28 Effective 2026-03-14 through 2026-04-04
Mon-Fri,Sun 14:26 Ronald Reagan Washington (DCA) 2 15:52 Madison (MSN) AA 5221 Non-stop Canadair CRJ 900 (CR9) 2:26 Effective 2026-03-08 through 2026-04-06
Daily 14:51 Madison (MSN) 18:00 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:09 Effective 2026-09-09 through 2026-10-04
Daily 15:47 Madison (MSN) 18:54 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:07 Effective from 2026-10-05
Daily 15:57 Madison (MSN) 19:00 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:03 Valid until 2026-01-05
Mon-Fri,Sun 15:57 Madison (MSN) 19:10 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:13 Effective 2026-01-06 through 2026-02-11
Sat 16:04 Madison (MSN) 19:15 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:11 Effective 2026-02-14 through 2026-03-07
Mon-Fri,Sun 16:05 Madison (MSN) 19:15 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 900 (CR9) 2:10 Effective 2026-02-12 through 2026-03-06
Sat 16:06 Madison (MSN) 19:15 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 700 (CR7) 2:09 Effective 2026-03-14 through 2026-04-04
Mon-Fri,Sun 16:22 Madison (MSN) 19:33 Ronald Reagan Washington (DCA) 2 AA 5221 Non-stop Canadair CRJ 900 (CR9) 2:11 Effective 2026-03-08 through 2026-04-06
Daily 18:05 Charlotte (CLT) 19:34 Washington Dulles (IAD) AA 5221 Non-stop Canadair CRJ 900 (CR9) 1:29 Effective 2026-05-21 through 2026-08-04
Daily 20:07 Washington Dulles (IAD) 21:50 Charlotte (CLT) AA 5221 Non-stop Canadair CRJ 900 (CR9) 1:43 Effective 2026-07-02 through 2026-08-04
Daily 20:14 Washington Dulles (IAD) 21:50 Charlotte (CLT) AA 5221 Non-stop Canadair CRJ 900 (CR9) 1:36 Effective 2026-05-21 through 2026-07-01

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This flight number is listed as serving the following routes:

Charlotte (CLT) - Washington Dulles (IAD)
Ronald Reagan Washington (DCA) - Detroit (DTW)
Ronald Reagan Washington (DCA) - Madison (MSN)

All American Airlines flights

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American Airlines flight AA 5221: Multiple routes

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FLIGHT SCHEDULE

Direct Flights:

American Airlines AA5221

07:29

Ronald Reagan Washington (DCA) 2

09:07

Detroit (DTW) E

Effective 2026-04-07 through 2026-05-20

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:38, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

09:25

Detroit (DTW) E

11:00

Ronald Reagan Washington (DCA) 2

Effective 2026-04-07 through 2026-05-20

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:35, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

11:30

Ronald Reagan Washington (DCA) 2

12:41

Madison (MSN)

Effective 2026-08-05 through 2026-09-08

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:11, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

12:59

Ronald Reagan Washington (DCA) 2

14:13

Madison (MSN)

Effective 2026-09-09 through 2026-10-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:14, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

13:12

Madison (MSN)

16:25

Ronald Reagan Washington (DCA) 2

Effective 2026-08-05 through 2026-09-08

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:13, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

13:44

Ronald Reagan Washington (DCA) 2

14:58

Madison (MSN)

Effective from 2026-10-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:14, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

13:54

Ronald Reagan Washington (DCA) 2

15:23

Madison (MSN)

Effective 2026-01-10 through 2026-02-07

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 2:29, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

13:58

Ronald Reagan Washington (DCA) 2

15:27

Madison (MSN)

Effective 2026-01-06 through 2026-02-11

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:29, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

13:59

Ronald Reagan Washington (DCA) 2

15:21

Madison (MSN)

Valid until 2026-01-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:22, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

13:59

Ronald Reagan Washington (DCA) 2

15:30

Madison (MSN)

Effective 2026-02-12 through 2026-03-06

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:31, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5221

14:01

Ronald Reagan Washington (DCA) 2

15:34

Madison (MSN)

Effective 2026-02-14 through 2026-03-07

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 2:33, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

14:01

Ronald Reagan Washington (DCA) 2

15:29

Madison (MSN)

Effective 2026-03-14 through 2026-04-04

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 2:28, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

14:26

Ronald Reagan Washington (DCA) 2

15:52

Madison (MSN)

Effective 2026-03-08 through 2026-04-06

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:26, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5221

14:51

Madison (MSN)

18:00

Ronald Reagan Washington (DCA) 2

Effective 2026-09-09 through 2026-10-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:09, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

15:47

Madison (MSN)

18:54

Ronald Reagan Washington (DCA) 2

Effective from 2026-10-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:07, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

15:57

Madison (MSN)

19:00

Ronald Reagan Washington (DCA) 2

Valid until 2026-01-05

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 2:03, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

15:57

Madison (MSN)

19:10

Ronald Reagan Washington (DCA) 2

Effective 2026-01-06 through 2026-02-11

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:13, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

16:04

Madison (MSN)

19:15

Ronald Reagan Washington (DCA) 2

Effective 2026-02-14 through 2026-03-07

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 2:11, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

16:05

Madison (MSN)

19:15

Ronald Reagan Washington (DCA) 2

Effective 2026-02-12 through 2026-03-06

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:10, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5221

16:06

Madison (MSN)

19:15

Ronald Reagan Washington (DCA) 2

Effective 2026-03-14 through 2026-04-04

Mon
-

Tue
-

Wed
-

Thu
-

Fri
-

Sat

Sun
-

Duration: 2:09, non-stop
Canadair CRJ 700 (CR7)

Direct Flights:

American Airlines AA5221

16:22

Madison (MSN)

19:33

Ronald Reagan Washington (DCA) 2

Effective 2026-03-08 through 2026-04-06

Mon

Tue

Wed

Thu

Fri

Sat
-

Sun

Duration: 2:11, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5221

18:05

Charlotte (CLT)

19:34

Washington Dulles (IAD)

Effective 2026-05-21 through 2026-08-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:29, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5221

20:07

Washington Dulles (IAD)

21:50

Charlotte (CLT)

Effective 2026-07-02 through 2026-08-04

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:43, non-stop
Canadair CRJ 900 (CR9)

Direct Flights:

American Airlines AA5221

20:14

Washington Dulles (IAD)

21:50

Charlotte (CLT)

Effective 2026-05-21 through 2026-07-01

Mon

Tue

Wed

Thu

Fri

Sat

Sun

Duration: 1:36, non-stop
Canadair CRJ 900 (CR9)

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This flight number is listed as serving the following routes:

Charlotte (CLT) - Washington Dulles (IAD)
Ronald Reagan Washington (DCA) - Detroit (DTW)
Ronald Reagan Washington (DCA) - Madison (MSN)

All American Airlines flights

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