American Airlines flight AA 4388: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 06:00 New York LaGuardia (LGA) B 07:22 Boston Logan (BOS) B
AA 4388 Non-stop Embraer EMB 175 (E75) 1:22 Effective 2026-07-02 through 2026-08-04
Daily 08:00 Boston Logan (BOS) B 09:21 New York LaGuardia (LGA) B
AA 4388 Non-stop Embraer EMB 175 (E75) 1:21 Effective 2026-07-02 through 2026-08-04
Daily 08:00 Chicago O'Hare (ORD) 3 10:12 Indianapolis (IND)
AA 4388 Non-stop Embraer EMB 175 (E75) 1:12 Effective 2026-09-09 through 2026-10-04
Daily 08:29 New York John F. Kennedy (JFK) 8 10:47 Cincinnati (CVG)
AA 4388 Non-stop Embraer EMB 175 (E75) 2:18 Effective 2026-08-05 through 2026-09-08
Daily 09:45 New York John F. Kennedy (JFK) 8 11:40 John Glenn Columbus (CMH)
AA 4388 Non-stop Embraer EMB 175 (E75) 1:55 Effective from 2026-10-05
Daily 10:53 Indianapolis (IND) 11:10 Chicago O'Hare (ORD) 3
AA 4388 Non-stop Embraer EMB 175 (E75) 1:17 Effective 2026-09-09 through 2026-10-04
Daily 11:23 Cincinnati (CVG) 13:29 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 175 (E75) 2:06 Effective 2026-08-05 through 2026-09-08
Mon,Sat,Sun 11:30 John Glenn Columbus (CMH) 13:29 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:59 Effective 2026-01-03 through 2026-01-05
Mon,Tue,Fri 11:31 John Glenn Columbus (CMH) 13:30 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:59 Valid until 2026-01-02
Daily 11:40 New York LaGuardia (LGA) B 13:24 Cleveland (CLE)
AA 4388 Non-stop Embraer EMB 175 (E75) 1:44 Effective 2026-05-21 through 2026-07-01
Daily 12:00 New York LaGuardia (LGA) B 13:31 Charlottesville (CHO)
AA 4388 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:31 Effective 2026-04-07 through 2026-05-20
Daily 12:35 John Glenn Columbus (CMH) 14:32 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 175 (E75) 1:57 Effective from 2026-10-05
Thu 12:50 John Glenn Columbus (CMH) 14:51 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 175 (E75) 2:01 Operates only on 2026-01-01
Daily 13:03 John Glenn Columbus (CMH) 14:59 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-02-12 through 2026-03-07
Mon-Fri,Sun 13:06 John Glenn Columbus (CMH) 14:59 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 175 (E75) 1:53 Effective 2026-01-06 through 2026-02-11
Sat 14:07 John Glenn Columbus (CMH) 16:00 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 175 (E75) 1:53 Effective 2026-01-10 through 2026-02-07
Daily 14:27 Charlottesville (CHO) 16:00 New York LaGuardia (LGA) B
AA 4388 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:33 Effective 2026-04-07 through 2026-05-20
Mon-Fri,Sun 15:49 Boston Logan (BOS) B 17:13 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 175 (E75) 1:24 Effective 2026-03-08 through 2026-04-06
Daily 15:54 Cleveland (CLE) 17:29 New York LaGuardia (LGA) B
AA 4388 Non-stop Embraer EMB 175 (E75) 1:35 Effective 2026-05-21 through 2026-07-01
Sat 16:20 Boston Logan (BOS) B 17:47 New York John F. Kennedy (JFK) 8
AA 4388 Non-stop Embraer EMB 175 (E75) 1:27 Effective 2026-03-14 through 2026-04-04
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4388: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4388
06:00
New York LaGuardia (LGA) B

07:22
Boston Logan (BOS) B
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:22, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
08:00
Boston Logan (BOS) B

09:21
New York LaGuardia (LGA) B
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:21, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
08:00
Chicago O'Hare (ORD) 3

10:12
Indianapolis (IND)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:12, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
08:29
New York John F. Kennedy (JFK) 8

10:47
Cincinnati (CVG)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:18, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
09:45
New York John F. Kennedy (JFK) 8

11:40
John Glenn Columbus (CMH)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:55, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
10:53
Indianapolis (IND)

11:10
Chicago O'Hare (ORD) 3
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:17, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
11:23
Cincinnati (CVG)

13:29
New York John F. Kennedy (JFK) 8
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:06, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
11:30
John Glenn Columbus (CMH)

13:29
New York John F. Kennedy (JFK) 8
Effective 2026-01-03 through 2026-01-05
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
Duration: 1:59, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4388
11:31
John Glenn Columbus (CMH)

13:30
New York John F. Kennedy (JFK) 8
Valid until 2026-01-02
Mon
Tue
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Duration: 1:59, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4388
11:40
New York LaGuardia (LGA) B

13:24
Cleveland (CLE)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:44, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
12:00
New York LaGuardia (LGA) B

13:31
Charlottesville (CHO)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:31, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4388
12:35
John Glenn Columbus (CMH)

14:32
New York John F. Kennedy (JFK) 8
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:57, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
12:50
John Glenn Columbus (CMH)

14:51
New York John F. Kennedy (JFK) 8
Operates only on 2026-01-01
Mon
-
Tue
-
Wed
-
Thu
Fri
-
Sat
-
Sun
-
Duration: 2:01, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
13:03
John Glenn Columbus (CMH)

14:59
New York John F. Kennedy (JFK) 8
Effective 2026-02-12 through 2026-03-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
13:06
John Glenn Columbus (CMH)

14:59
New York John F. Kennedy (JFK) 8
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:53, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
14:07
John Glenn Columbus (CMH)

16:00
New York John F. Kennedy (JFK) 8
Effective 2026-01-10 through 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:53, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
14:27
Charlottesville (CHO)

16:00
New York LaGuardia (LGA) B
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:33, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4388
15:49
Boston Logan (BOS) B

17:13
New York John F. Kennedy (JFK) 8
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
15:54
Cleveland (CLE)

17:29
New York LaGuardia (LGA) B
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:35, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4388
16:20
Boston Logan (BOS) B

17:47
New York John F. Kennedy (JFK) 8
Effective 2026-03-14 through 2026-04-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:27, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Boston Logan (BOS) - New York John F. Kennedy (JFK)
  • Boston Logan (BOS) - New York LaGuardia (LGA)
  • Chicago O'Hare (ORD) - Indianapolis (IND)
  • Cleveland (CLE) - New York LaGuardia (LGA)
  • John Glenn Columbus (CMH) - New York John F. Kennedy (JFK)
  • New York John F. Kennedy (JFK) - Cincinnati (CVG)
  • New York LaGuardia (LGA) - Charlottesville (CHO)
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