American Airlines flight AA 4380: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 08:27 New York John F. Kennedy (JFK) 8 10:45 Cincinnati (CVG)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:18 Effective 2026-09-09 through 2026-10-04
Mon-Fri 09:00 New York LaGuardia (LGA) B 11:10 John Glenn Columbus (CMH)
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:10 Effective 2026-01-06 through 2026-02-11
Mon,Thu,Fri 09:15 New York LaGuardia (LGA) B 11:18 John Glenn Columbus (CMH)
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:03 Effective 2026-03-09 through 2026-04-06
Mon-Fri 09:25 New York LaGuardia (LGA) B 11:33 John Glenn Columbus (CMH)
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:08 Effective 2026-02-12 through 2026-03-06
Tue,Wed 09:29 New York LaGuardia (LGA) B 11:32 John Glenn Columbus (CMH)
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 2:03 Effective 2026-03-10 through 2026-04-01
Mon-Fri 11:40 John Glenn Columbus (CMH) 13:31 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:51 Effective 2026-01-06 through 2026-02-11
Sun 11:46 John Glenn Columbus (CMH) 13:37 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:51 Effective 2026-01-11 through 2026-02-08
Sun 11:46 John Glenn Columbus (CMH) 13:43 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:57 Effective 2026-02-15 through 2026-03-01
Sun 11:56 John Glenn Columbus (CMH) 13:43 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:47 Effective 2026-03-08 through 2026-04-05
Mon,Thu,Fri 11:58 John Glenn Columbus (CMH) 13:45 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:47 Effective 2026-03-09 through 2026-04-06
Mon-Fri 12:03 John Glenn Columbus (CMH) 13:59 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:56 Effective 2026-02-12 through 2026-03-06
Tue,Wed 12:07 John Glenn Columbus (CMH) 13:54 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:47 Effective 2026-03-10 through 2026-04-01
Daily 12:27 Cincinnati (CVG) 14:35 New York John F. Kennedy (JFK) 8
AA 4380 Non-stop Embraer EMB 175 (E75) 2:08 Effective 2026-09-09 through 2026-10-04
Daily 12:50 Chicago O'Hare (ORD) 3 13:59 Madison (MSN)
AA 4380 Non-stop Embraer EMB 175 (E75) 1:09 Valid until 2026-01-05
Daily 13:15 New York LaGuardia (LGA) B 15:20 Columbia (CAE)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:05 Effective 2026-05-21 through 2026-07-01
Daily 13:20 Ronald Reagan Washington (DCA) 2 14:54 Boston Logan (BOS) B
AA 4380 Non-stop Embraer EMB 175 (E75) 1:34 Effective 2026-07-02 through 2026-08-04
Daily 14:18 Boston Logan (BOS) B 15:45 New York John F. Kennedy (JFK) 8
AA 4380 Non-stop Embraer EMB 175 (E75) 1:27 Effective 2026-04-07 through 2026-05-20
Daily 14:30 Madison (MSN) 15:48 Chicago O'Hare (ORD) 3
AA 4380 Non-stop Embraer EMB 175 (E75) 1:18 Valid until 2026-01-05
Daily 14:37 New York LaGuardia (LGA) B 16:06 Nashville (BNA)
AA 4380 Non-stop Embraer EMB 175 (E75) 2:29 Effective from 2026-10-05
Daily 15:24 Boston Logan (BOS) B 17:20 Ronald Reagan Washington (DCA) 2
AA 4380 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-07-02 through 2026-08-04
Daily 16:04 Columbia (CAE) 18:00 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-05-21 through 2026-07-01
Daily 17:37 Nashville (BNA) 21:01 New York LaGuardia (LGA) B
AA 4380 Non-stop Embraer EMB 175 (E75) 2:24 Effective 2026-08-05 through 2026-09-08
Sat 21:15 Miami (MIA) 23:59 Cedar Rapids (CID)
AA 4380 Non-stop Embraer EMB 175 (E75) 3:44 Effective 2026-03-14 through 2026-04-04
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4380: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4380
08:27
New York John F. Kennedy (JFK) 8

10:45
Cincinnati (CVG)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:18, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
09:00
New York LaGuardia (LGA) B

11:10
John Glenn Columbus (CMH)
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 2:10, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
09:15
New York LaGuardia (LGA) B

11:18
John Glenn Columbus (CMH)
Effective 2026-03-09 through 2026-04-06
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
-
Duration: 2:03, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
09:25
New York LaGuardia (LGA) B

11:33
John Glenn Columbus (CMH)
Effective 2026-02-12 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 2:08, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
09:29
New York LaGuardia (LGA) B

11:32
John Glenn Columbus (CMH)
Effective 2026-03-10 through 2026-04-01
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:03, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
11:40
John Glenn Columbus (CMH)

13:31
New York LaGuardia (LGA) B
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 1:51, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
11:46
John Glenn Columbus (CMH)

13:37
New York LaGuardia (LGA) B
Effective 2026-01-11 through 2026-02-08
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:51, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
11:46
John Glenn Columbus (CMH)

13:43
New York LaGuardia (LGA) B
Effective 2026-02-15 through 2026-03-01
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:57, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
11:56
John Glenn Columbus (CMH)

13:43
New York LaGuardia (LGA) B
Effective 2026-03-08 through 2026-04-05
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:47, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
11:58
John Glenn Columbus (CMH)

13:45
New York LaGuardia (LGA) B
Effective 2026-03-09 through 2026-04-06
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
-
Duration: 1:47, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
12:03
John Glenn Columbus (CMH)

13:59
New York LaGuardia (LGA) B
Effective 2026-02-12 through 2026-03-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 1:56, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
12:07
John Glenn Columbus (CMH)

13:54
New York LaGuardia (LGA) B
Effective 2026-03-10 through 2026-04-01
Mon
-
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:47, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4380
12:27
Cincinnati (CVG)

14:35
New York John F. Kennedy (JFK) 8
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:08, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
12:50
Chicago O'Hare (ORD) 3

13:59
Madison (MSN)
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:09, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
13:15
New York LaGuardia (LGA) B

15:20
Columbia (CAE)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:05, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
13:20
Ronald Reagan Washington (DCA) 2

14:54
Boston Logan (BOS) B
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:34, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
14:18
Boston Logan (BOS) B

15:45
New York John F. Kennedy (JFK) 8
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:27, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
14:30
Madison (MSN)

15:48
Chicago O'Hare (ORD) 3
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:18, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
14:37
New York LaGuardia (LGA) B

16:06
Nashville (BNA)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:29, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
15:24
Boston Logan (BOS) B

17:20
Ronald Reagan Washington (DCA) 2
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
16:04
Columbia (CAE)

18:00
New York LaGuardia (LGA) B
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
17:37
Nashville (BNA)

21:01
New York LaGuardia (LGA) B
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4380
21:15
Miami (MIA)

23:59
Cedar Rapids (CID)
Effective 2026-03-14 through 2026-04-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 3:44, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Boston Logan (BOS) - New York John F. Kennedy (JFK)
  • Boston Logan (BOS) - Ronald Reagan Washington (DCA)
  • Columbia (CAE) - New York LaGuardia (LGA)
  • Madison (MSN) - Chicago O'Hare (ORD)
  • Miami (MIA) - Cedar Rapids (CID)
  • New York John F. Kennedy (JFK) - Cincinnati (CVG)
  • New York LaGuardia (LGA) - John Glenn Columbus (CMH)
  • New York LaGuardia (LGA) - Nashville (BNA)
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