American Airlines flight AA 4378: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Wed 09:30 New York John F. Kennedy (JFK) 8 11:31 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 2:01 Operates only on 2026-03-04
Wed 09:40 New York John F. Kennedy (JFK) 8 11:41 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 2:01 Effective 2026-02-18 through 2026-02-25
Daily 09:40 New York John F. Kennedy (JFK) 8 11:29 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 1:49 Effective 2026-09-09 through 2026-10-04
Daily 09:45 New York LaGuardia (LGA) B 10:58 Boston Logan (BOS) B
AA 4378 Non-stop Embraer EMB 175 (E75) 1:13 Effective 2026-04-07 through 2026-05-20
Wed 09:50 New York John F. Kennedy (JFK) 8 11:46 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-01-07 through 2026-02-11
Mon,Tue,Thu,Fri,Sun 09:55 New York John F. Kennedy (JFK) 8 11:56 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 2:01 Effective 2026-02-12 through 2026-03-06
Mon,Tue,Thu-Sat 09:59 New York John F. Kennedy (JFK) 8 11:55 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-01-06 through 2026-01-24
Mon,Tue,Thu-Sat 09:59 New York John F. Kennedy (JFK) 8 11:55 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-02-02 through 2026-02-10
Mon,Tue,Thu-Sat 10:00 New York John F. Kennedy (JFK) 8 11:56 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-01-26 through 2026-01-31
Sun 10:30 New York John F. Kennedy (JFK) 8 12:26 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 1:56 Effective 2026-01-11 through 2026-02-08
Sat 10:33 Ronald Reagan Washington (DCA) 2 12:45 Atlanta (ATL) N
AA 4378 Non-stop Embraer EMB 175 (E75) 2:12 Effective 2026-03-14 through 2026-04-04
Mon-Fri,Sun 10:35 Ronald Reagan Washington (DCA) 2 12:47 Atlanta (ATL) N
AA 4378 Non-stop Embraer EMB 175 (E75) 2:12 Effective 2026-03-08 through 2026-04-06
Mon,Tue,Fri-Sun 11:00 New York John F. Kennedy (JFK) 8 12:50 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 1:50 Valid until 2026-01-05
Sat 11:15 New York John F. Kennedy (JFK) 8 13:16 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 2:01 Effective 2026-02-14 through 2026-03-07
Daily 12:30 Boston Logan (BOS) B 13:47 New York LaGuardia (LGA) B
AA 4378 Non-stop Embraer EMB 175 (E75) 1:17 Effective 2026-04-07 through 2026-05-20
Daily 13:18 Atlanta (ATL) N 15:13 Ronald Reagan Washington (DCA) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 1:55 Effective 2026-03-08 through 2026-04-06
Daily 13:30 New York John F. Kennedy (JFK) 8 15:21 Raleigh/Durham (RDU) 2
AA 4378 Non-stop Embraer EMB 175 (E75) 1:51 Effective 2026-08-05 through 2026-09-08
Daily 14:45 New York LaGuardia (LGA) B 16:08 Boston Logan (BOS) B
AA 4378 Non-stop Embraer EMB 175 (E75) 1:23 Effective 2026-07-02 through 2026-08-04
Daily 14:59 New York LaGuardia (LGA) B 16:45 Cleveland (CLE)
AA 4378 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:46 Effective from 2026-10-05
Daily 16:10 New York LaGuardia (LGA) B 17:34 Buffalo (BUF)
AA 4378 Non-stop Embraer EMB 175 (E75) 1:24 Effective 2026-05-21 through 2026-07-01
Daily 16:38 Boston Logan (BOS) B 18:02 New York LaGuardia (LGA) B
AA 4378 Non-stop Embraer EMB 175 (E75) 1:24 Effective 2026-07-02 through 2026-08-04
Daily 17:25 Cleveland (CLE) 18:59 New York LaGuardia (LGA) B
AA 4378 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:34 Effective from 2026-10-05
Daily 18:06 Buffalo (BUF) 19:29 New York LaGuardia (LGA) B
AA 4378 Non-stop Embraer EMB 175 (E75) 1:23 Effective 2026-05-21 through 2026-07-01
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4378: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4378
09:30
New York John F. Kennedy (JFK) 8

11:31
Raleigh/Durham (RDU) 2
Operates only on 2026-03-04
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:01, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
09:40
New York John F. Kennedy (JFK) 8

11:41
Raleigh/Durham (RDU) 2
Effective 2026-02-18 through 2026-02-25
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 2:01, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
09:40
New York John F. Kennedy (JFK) 8

11:29
Raleigh/Durham (RDU) 2
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:49, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
09:45
New York LaGuardia (LGA) B

10:58
Boston Logan (BOS) B
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:13, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
09:50
New York John F. Kennedy (JFK) 8

11:46
Raleigh/Durham (RDU) 2
Effective 2026-01-07 through 2026-02-11
Mon
-
Tue
-
Wed
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
09:55
New York John F. Kennedy (JFK) 8

11:56
Raleigh/Durham (RDU) 2
Effective 2026-02-12 through 2026-03-06
Mon
Tue
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 2:01, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
09:59
New York John F. Kennedy (JFK) 8

11:55
Raleigh/Durham (RDU) 2
Effective 2026-01-06 through 2026-01-24
Mon
Tue
Wed
-
Thu
Fri
Sat
Sun
-
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
09:59
New York John F. Kennedy (JFK) 8

11:55
Raleigh/Durham (RDU) 2
Effective 2026-02-02 through 2026-02-10
Mon
Tue
Wed
-
Thu
Fri
Sat
Sun
-
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
10:00
New York John F. Kennedy (JFK) 8

11:56
Raleigh/Durham (RDU) 2
Effective 2026-01-26 through 2026-01-31
Mon
Tue
Wed
-
Thu
Fri
Sat
Sun
-
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
10:30
New York John F. Kennedy (JFK) 8

12:26
Raleigh/Durham (RDU) 2
Effective 2026-01-11 through 2026-02-08
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:56, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
10:33
Ronald Reagan Washington (DCA) 2

12:45
Atlanta (ATL) N
Effective 2026-03-14 through 2026-04-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:12, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
10:35
Ronald Reagan Washington (DCA) 2

12:47
Atlanta (ATL) N
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:12, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
11:00
New York John F. Kennedy (JFK) 8

12:50
Raleigh/Durham (RDU) 2
Valid until 2026-01-05
Mon
Tue
Wed
-
Thu
-
Fri
Sat
Sun
Duration: 1:50, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
11:15
New York John F. Kennedy (JFK) 8

13:16
Raleigh/Durham (RDU) 2
Effective 2026-02-14 through 2026-03-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 2:01, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
12:30
Boston Logan (BOS) B

13:47
New York LaGuardia (LGA) B
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:17, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
13:18
Atlanta (ATL) N

15:13
Ronald Reagan Washington (DCA) 2
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:55, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
13:30
New York John F. Kennedy (JFK) 8

15:21
Raleigh/Durham (RDU) 2
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:51, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
14:45
New York LaGuardia (LGA) B

16:08
Boston Logan (BOS) B
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:23, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
14:59
New York LaGuardia (LGA) B

16:45
Cleveland (CLE)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:46, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4378
16:10
New York LaGuardia (LGA) B

17:34
Buffalo (BUF)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
16:38
Boston Logan (BOS) B

18:02
New York LaGuardia (LGA) B
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:24, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4378
17:25
Cleveland (CLE)

18:59
New York LaGuardia (LGA) B
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:34, non-stop
Embraer EMB 170 / EMB 175 (E70)
Direct Flights:
American Airlines AA4378
18:06
Buffalo (BUF)

19:29
New York LaGuardia (LGA) B
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:23, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Atlanta (ATL) - Ronald Reagan Washington (DCA)
  • Boston Logan (BOS) - New York LaGuardia (LGA)
  • Buffalo (BUF) - New York LaGuardia (LGA)
  • Cleveland (CLE) - New York LaGuardia (LGA)
  • New York John F. Kennedy (JFK) - Raleigh/Durham (RDU)
All American Airlines flights
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