American Airlines flight AA 4281: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Mon,Thu,Fri,Sun 16:57 Charleston (CHS) 18:44 Chicago O'Hare (ORD) 3
AA 4281 Non-stop Embraer EMB 175 (E75) 2:47 Effective 2026-02-12 through 2026-03-06
Sun 16:59 Charleston (CHS) 18:47 Chicago O'Hare (ORD) 3
AA 4281 Non-stop Embraer EMB 175 (E75) 2:48 Effective 2026-03-08 through 2026-04-05
Mon-Fri 17:09 Charleston (CHS) 19:01 Chicago O'Hare (ORD) 3
AA 4281 Non-stop Embraer EMB 175 (E75) 2:52 Effective 2026-03-09 through 2026-04-06
Daily 21:30 Dallas Fort Worth (DFW) 22:53 Amarillo (AMA)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:23 Effective 2026-01-06 through 2026-01-18
Daily 21:30 Dallas Fort Worth (DFW) 22:53 Amarillo (AMA)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:23 Effective 2026-01-20 through 2026-02-06
Mon-Wed,Sun 21:30 Dallas Fort Worth (DFW) 22:53 Amarillo (AMA)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:23 Effective 2026-02-08 through 2026-02-11
Daily 21:46 Chicago O'Hare (ORD) 3 23:50 Tulsa (TUL)
AA 4281 Non-stop Embraer EMB 175 (E75) 2:04 Effective 2026-07-02 through 2026-08-04
Daily 22:00 Chicago O'Hare (ORD) 3 23:59 Tulsa (TUL)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:59 Effective 2026-05-21 through 2026-07-01
Daily 22:15 Chicago O'Hare (ORD) 3 00:14 Tulsa (TUL)
AA 4281 Non-stop Embraer EMB 170 / EMB 175 (E70) 1:59 Effective 2026-09-09 through 2026-10-04
The flight arrives 1 day after departure.
Daily 22:20 Chicago O'Hare (ORD) 3 00:20 Tulsa (TUL)
AA 4281 Non-stop Embraer EMB 175 (E75) 2:00 Effective 2026-08-05 through 2026-09-08
The flight arrives 1 day after departure.
Mon,Tue,Thu-Sun 22:39 Dallas Fort Worth (DFW) 23:54 Amarillo (AMA)
AA 4281 Non-stop Embraer EMB 175 (E75) 1:15 Valid until 2026-01-04
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4281: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4281
16:57
Charleston (CHS)

18:44
Chicago O'Hare (ORD) 3
Effective 2026-02-12 through 2026-03-06
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 2:47, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4281
16:59
Charleston (CHS)

18:47
Chicago O'Hare (ORD) 3
Effective 2026-03-08 through 2026-04-05
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 2:48, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4281
17:09
Charleston (CHS)

19:01
Chicago O'Hare (ORD) 3
Effective 2026-03-09 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
-
Duration: 2:52, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4281
21:30
Dallas Fort Worth (DFW)

22:53
Amarillo (AMA)
Effective 2026-01-06 through 2026-01-18
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:23, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4281
21:30
Dallas Fort Worth (DFW)

22:53
Amarillo (AMA)
Effective 2026-01-20 through 2026-02-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:23, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4281
21:30
Dallas Fort Worth (DFW)

22:53
Amarillo (AMA)
Effective 2026-02-08 through 2026-02-11
Mon
Tue
Wed
Thu
-
Fri
-
Sat
-
Sun
Duration: 1:23, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4281
21:46
Chicago O'Hare (ORD) 3

23:50
Tulsa (TUL)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:04, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4281
22:00
Chicago O'Hare (ORD) 3

23:59
Tulsa (TUL)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:59, non-stop
Embraer EMB 175 (E75)
Direct Flights:
American Airlines AA4281
22:15
Chicago O'Hare (ORD) 3

00:14(+1)
Tulsa (TUL)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:59, non-stop
Embraer EMB 170 / EMB 175 (E70)
The flight arrives 1 day after departure.
Direct Flights:
American Airlines AA4281
22:20
Chicago O'Hare (ORD) 3

00:20(+1)
Tulsa (TUL)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:00, non-stop
Embraer EMB 175 (E75)
The flight arrives 1 day after departure.
Direct Flights:
American Airlines AA4281
22:39
Dallas Fort Worth (DFW)

23:54
Amarillo (AMA)
Valid until 2026-01-04
Mon
Tue
Wed
-
Thu
Fri
Sat
Sun
Duration: 1:15, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Charleston (CHS) - Chicago O'Hare (ORD)
  • Chicago O'Hare (ORD) - Tulsa (TUL)
  • Dallas Fort Worth (DFW) - Amarillo (AMA)
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