American Airlines flight AA 381: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 05:35 Seattle-Tacoma (SEA) 13:41 Charlotte (CLT)
AA 381 Non-stop Airbus A321 (321) 5:06 Effective 2026-08-05 through 2026-09-08
Daily 05:49 Seattle-Tacoma (SEA) 14:00 Charlotte (CLT)
AA 381 Non-stop Airbus A321 (321) 5:11 Effective 2026-09-09 through 2026-10-04
Daily 05:54 Seattle-Tacoma (SEA) 14:00 Charlotte (CLT)
AA 381 Non-stop Airbus A321 (321) 5:06 Effective 2026-07-02 through 2026-08-04
Daily 05:57 Seattle-Tacoma (SEA) 14:00 Charlotte (CLT)
AA 381 Non-stop Airbus A321 (321) 5:03 Effective 2026-05-21 through 2026-07-01
Daily 07:38 Seattle-Tacoma (SEA) 15:45 Charlotte (CLT)
AA 381 Non-stop Airbus A321 (321) 5:07 Effective 2026-04-07 through 2026-05-20
Daily 08:25 Miami (MIA) 10:07 Palmerola, Tegucigalpa (XPL)
AA 381 Non-stop Airbus A319 (319) 2:42 Effective 2026-01-07 through 2026-01-13
Mon,Sun 17:10 Los Angeles (LAX) 21:00 Honolulu (HNL) 2
AA 381 Non-stop Airbus A321neo (32Q) 5:50 Valid until 2026-01-04
Wed,Fri,Sun 21:35 Miami (MIA) 07:50 Santiago (SCL) 2
AA 381 Non-stop Boeing 787-8 (788) 8:15 Effective 2026-02-13 through 2026-03-01
The flight arrives 1 day after departure.
Mon,Sun 22:31 Honolulu (HNL) 2 06:00 Los Angeles (LAX)
AA 381 Non-stop Airbus A321neo (32Q) 5:29 Valid until 2026-01-04
The flight arrives 1 day after departure.
Mon 23:33 Honolulu (HNL) 2 07:02 Los Angeles (LAX)
AA 381 Non-stop Airbus A321neo (32Q) 5:29 Operates only on 2026-01-05
The flight arrives 1 day after departure.
Tue-Sat 23:45 Honolulu (HNL) 2 07:14 Los Angeles (LAX)
AA 381 Non-stop Airbus A321neo (32Q) 5:29 Valid until 2026-01-03
The flight arrives 1 day after departure.
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This flight number is listed as serving the following routes:


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American Airlines flight AA 381: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA381
05:35
Seattle-Tacoma (SEA)

13:41
Charlotte (CLT)
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 5:06, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA381
05:49
Seattle-Tacoma (SEA)

14:00
Charlotte (CLT)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 5:11, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA381
05:54
Seattle-Tacoma (SEA)

14:00
Charlotte (CLT)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 5:06, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA381
05:57
Seattle-Tacoma (SEA)

14:00
Charlotte (CLT)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 5:03, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA381
07:38
Seattle-Tacoma (SEA)

15:45
Charlotte (CLT)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 5:07, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA381
08:25
Miami (MIA)

10:07
Palmerola, Tegucigalpa (XPL)
Effective 2026-01-07 through 2026-01-13
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:42, non-stop
Airbus A319 (319)
Direct Flights:
American Airlines AA381
17:10
Los Angeles (LAX)

21:00
Honolulu (HNL) 2
Valid until 2026-01-04
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 5:50, non-stop
Airbus A321neo (32Q)
Direct Flights:
American Airlines AA381
21:35
Miami (MIA)

07:50(+1)
Santiago (SCL) 2
Effective 2026-02-13 through 2026-03-01
Mon
-
Tue
-
Wed
Thu
-
Fri
Sat
-
Sun
Duration: 8:15, non-stop
Boeing 787-8 (788)
The flight arrives 1 day after departure.
Direct Flights:
American Airlines AA381
22:31
Honolulu (HNL) 2

06:00(+1)
Los Angeles (LAX)
Valid until 2026-01-04
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
Duration: 5:29, non-stop
Airbus A321neo (32Q)
The flight arrives 1 day after departure.
Direct Flights:
American Airlines AA381
23:33
Honolulu (HNL) 2

07:02(+1)
Los Angeles (LAX)
Operates only on 2026-01-05
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 5:29, non-stop
Airbus A321neo (32Q)
The flight arrives 1 day after departure.
Direct Flights:
American Airlines AA381
23:45
Honolulu (HNL) 2

07:14(+1)
Los Angeles (LAX)
Valid until 2026-01-03
Mon
-
Tue
Wed
Thu
Fri
Sat
Sun
-
Duration: 5:29, non-stop
Airbus A321neo (32Q)
The flight arrives 1 day after departure.
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This flight number is listed as serving the following routes:
  • Honolulu (HNL) - Los Angeles (LAX)
  • Miami (MIA) - Palmerola, Tegucigalpa (XPL)
  • Miami (MIA) - Santiago (SCL)
  • Seattle-Tacoma (SEA) - Charlotte (CLT)
All American Airlines flights
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