American Airlines flight AA 1543: Multiple routes

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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
Daily 07:05 Charlotte (CLT) 08:48 Las Vegas Harry Reid (LAS) 1
AA 1543 Non-stop Airbus A321 (321) 4:43 Effective 2026-09-09 through 2026-10-04
Daily 09:55 Las Vegas Harry Reid (LAS) 1 17:30 Charlotte (CLT)
AA 1543 Non-stop Airbus A321 (321) 4:35 Effective 2026-09-09 through 2026-10-04
Sat 16:40 Cincinnati (CVG) 18:07 Charlotte (CLT)
AA 1543 Non-stop Airbus A321 (321) 1:27 Valid until 2026-01-03
Daily 16:45 Chicago O'Hare (ORD) 3 19:02 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:17 Effective 2026-05-21 through 2026-07-01
Daily 16:45 Chicago O'Hare (ORD) 3 19:04 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:19 Effective 2026-07-02 through 2026-08-04
Daily 16:45 Chicago O'Hare (ORD) 3 19:08 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:23 Effective from 2026-10-05
Daily 16:55 Chicago O'Hare (ORD) 3 19:16 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:21 Effective 2026-08-05 through 2026-09-08
Mon,Thu,Fri,Sun 17:32 Chicago O'Hare (ORD) 3 19:59 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:27 Valid until 2026-01-05
Daily 17:49 Chicago O'Hare (ORD) 3 20:23 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:34 Effective 2026-02-12 through 2026-03-07
Mon-Thu,Sat,Sun 17:49 Chicago O'Hare (ORD) 3 20:35 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:46 Effective 2026-03-08 through 2026-04-06
Fri 19:05 Chicago O'Hare (ORD) 3 21:51 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:46 Effective 2026-03-13 through 2026-04-03
Daily 19:50 Chicago O'Hare (ORD) 3 22:26 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:36 Effective 2026-01-06 through 2026-01-16
Daily 19:50 Chicago O'Hare (ORD) 3 22:26 San Diego (SAN) 2
AA 1543 Non-stop Boeing 737-800 (738) 4:36 Effective 2026-01-18 through 2026-02-11
Daily 23:59 Las Vegas Harry Reid (LAS) 1 07:40 Philadelphia (PHL)
AA 1543 Non-stop Airbus A321 (321) 4:41 Effective 2026-04-07 through 2026-05-20
The flight arrives 1 day after departure.
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This flight number is listed as serving the following routes:


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American Airlines flight AA 1543: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA1543
07:05
Charlotte (CLT)

08:48
Las Vegas Harry Reid (LAS) 1
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:43, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA1543
09:55
Las Vegas Harry Reid (LAS) 1

17:30
Charlotte (CLT)
Effective 2026-09-09 through 2026-10-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:35, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA1543
16:40
Cincinnati (CVG)

18:07
Charlotte (CLT)
Valid until 2026-01-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:27, non-stop
Airbus A321 (321)
Direct Flights:
American Airlines AA1543
16:45
Chicago O'Hare (ORD) 3

19:02
San Diego (SAN) 2
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:17, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
16:45
Chicago O'Hare (ORD) 3

19:04
San Diego (SAN) 2
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:19, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
16:45
Chicago O'Hare (ORD) 3

19:08
San Diego (SAN) 2
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:23, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
16:55
Chicago O'Hare (ORD) 3

19:16
San Diego (SAN) 2
Effective 2026-08-05 through 2026-09-08
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:21, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
17:32
Chicago O'Hare (ORD) 3

19:59
San Diego (SAN) 2
Valid until 2026-01-05
Mon
Tue
-
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 4:27, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
17:49
Chicago O'Hare (ORD) 3

20:23
San Diego (SAN) 2
Effective 2026-02-12 through 2026-03-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:34, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
17:49
Chicago O'Hare (ORD) 3

20:35
San Diego (SAN) 2
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
-
Sat
Sun
Duration: 4:46, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
19:05
Chicago O'Hare (ORD) 3

21:51
San Diego (SAN) 2
Effective 2026-03-13 through 2026-04-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Duration: 4:46, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
19:50
Chicago O'Hare (ORD) 3

22:26
San Diego (SAN) 2
Effective 2026-01-06 through 2026-01-16
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:36, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
19:50
Chicago O'Hare (ORD) 3

22:26
San Diego (SAN) 2
Effective 2026-01-18 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:36, non-stop
Boeing 737-800 (738)
Direct Flights:
American Airlines AA1543
23:59
Las Vegas Harry Reid (LAS) 1

07:40(+1)
Philadelphia (PHL)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:41, non-stop
Airbus A321 (321)
The flight arrives 1 day after departure.
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This flight number is listed as serving the following routes:
  • Chicago O'Hare (ORD) - San Diego (SAN)
  • Cincinnati (CVG) - Charlotte (CLT)
  • Las Vegas Harry Reid (LAS) - Charlotte (CLT)
  • Las Vegas Harry Reid (LAS) - Philadelphia (PHL)
All American Airlines flights
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